Structural domains that are shared by some of the perilipin family of proteins are depicted in shades of black and grey. The N terminus of perilipin 5 contains 100 amino acid (AA) sequences that are highly conserved between perilipin 1, 2, 3 but not 4 (PAT-1 domain, (black)). Overlapping with these sequences are stretches of amino acids containing 11-mer repeat sequences, a common feature for all perilipin proteins (PAT-2 domain, (medium grey)). The C-terminus of perilipin 5 contains a highly conserved sequence of 14 amino acids that folds into a hydrophobic cleft in perilipin 2, 3 and 4 but not in perilipin 1 (light grey). Unique to perilipin 5 are the ATGL and CGI-58 binding domain (blue) between 189 amino acids (AA) and 391 AA as well as a mitochondria-binding domain between 443 AA and 463 AA (yellow).