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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Trends Endocrinol Metab. 2011 May 31;22(6):197–203. doi: 10.1016/j.tem.2011.03.008

Table 1.

Shared and different properties between murine perilipin 1 and 5

perilipin proteins Perilipin 1 references Perilipin 5 references
Tissue distribution Specific

  • Adipose tissues (WAT and BAT)

  • Steroidogenic tissues

 [68–69] Specific

  • Cardiac skeletal muscle

  • BAT

  • Skeletal muscle (slow-twitched)

  • Liver

 [50–52]
Tissue energetic function Storage Utilization [50–52]
Cell localization Lipid droplet surface Cytosol/lipid droplet surface
Metabolic pathway Lipid droplet hydrolysis [70] Lipid droplet hydrolysis [50]
Shared structural features with perilipin protein family

  • PAT-1 domain

  • 11-mer repeats

 [32]

  • PAT-1 domain,

  • 11-mer repeats regions

  • Hydrophobic cleft

 [50]
Unique sequence features Hydrophobic sequences [71] Binding domains for mitochondria recruitment [66]
Scaffolding properties

  • HSL

  • CGI-58

 [44-46,48]

  • HSL

  • CGI-58

  • ATGL

 [46,53–55]
Regulation

  • At least 6 known PKA phosphorylation sites

  • Established[PPARγ] downstream target

 [41–42]
[72]

  • Incorporation of 32P PKA activation (phosphorylation sites unknown)

  • Presumed [PPARα] downstream target

 [55]
[50–52]