Table 3.
Baseline characteristics of trial participants
| Characteristic | Antioxidant group(n=19) | Control group (n=20) | P value |
|---|---|---|---|
| Organ dysfunction# (day 7) | 7 (37) | 8 (40) | 1.0 |
| MODS (IQR)+ | 1.59 (0–3) | 1.26 (0–3) | 0.08 |
| Length of hospital stay (days) | |||
| Mean (SD)* | 12.8 (3.9) | 15.1 (5.43) | 0.29 |
| Median (range) | 13 (9–21) | 15 (3–22) | |
| Duration of pain, days | |||
| Median (range) | 5 (2–7) | 5 (2–8) | - |
| Improvement at day 7 (based on clinical and laboratory parameters)# | 9/14 | 6/15 | 0.06 |
| Target organ dysfunction (day 7) Renal insufficiency# | 4 | 4 | 1.0 |
| Pulmonary insufficiency# | 1 | 3 | 0.60 |
| Abscess# | 2 | 4 | 0.65 |
| Difference in complication scores at outcome (SD)$ | 7.2 (12.9) | .71 (1.26) | .034 |
| Laboratory markers (change from day 0 to day 7), mean (SD)* | |||
| MDA (μmol/l) | –1.6 (1.9) | –1.5 (1.75) | 6.4 (8.9) |
| GSH (mmol/l) | 1.1 (0.7) | 1.3 (1.7) | 0.68 |
| SOD (IU/dl) | 5.4 (7.5) | 0.64 | 0.74 |
| Patient outcome,(%) | |||
| Discharge | 14 (100) | 13 (86) | 0.48 |
| Death# | 0 (0) | 2 (14) |
$
Adjusted for differences at baseline, compared by Univariate analysis
*
Student’s unpaired t test
#
Fisher exact test
+
Mann-Whitney U test. MDA: malondialdehyde; GSH: reduced glutathione; SOD: superoxide dismutase