Figure 6.

Yeast CatD's functions in cell metabolism. Besides its central role in the vacuolar proteolytic system, where it is a pivotal player for general protein turnover and maturation of several vacuolar hydrolases, the yeast ortholog of CatD, Pep4p, also holds a non-proteolytic function associated with its propeptide that promotes survival via polyamine-mediated reduction of programmed necrosis. In addition, yeast CatD might be involved in the induction of PCD in specific scenarios, as it has been described for its mammalian counterpart