Table 2.

Genome-wide association results for SNPs associated with WMH burden at P<1×10⁻⁵.

SNP ID	Chr	Position (build 36.3)	Risk allele	Allele freq.	SNP function	Nearest gene/transcript	Distance from gene (kb)	Direction of association in each cohort*	P	Number of additional SNPs associated at
										P<10−5	P<10−4
rs3744028	17	71400267	C	0.18	Intronic	TRIM65	0	+++++++	4.0×10−9	8	8
rs1055129	17	71384543	G	0.30	Intronic	TRIM47	0	+++++−+	4.1×10−8	13	18
rs7894407	10	105166169	T	0.63	Intronic	PDCD11	0	++−++++	6.1×10−7	4	13
rs1892525	1	68128202	G	0.69	Within transcribed sequence	RP11-518D3.1	0	+++++++	7.2×10−7	10	29
rs10814323	9	36021610	A	0.21	Intergenic	RECK	−5.3	+++++++	1.7×10−6	0	17
rs6992136	8	15786858	G	0.85	Intergenic	RPL32P19	−58.1	+−+++++	3.2×10−6	8	9
rs11731436	4	66437855	C	0.64	Intergenic	AC097110.1	−82.1	+++++++	3.3×10−6	0	22
rs1052053	1	154468797	A	0.62	Missense	PMF1	0	+++++−−	5.0×10−6	2	12
rs2167089	3	29009407	G	0.73	Intronic	AC098970.2	0	+++++++	6.0×10−6	0	0
rs10012573	4	110168035	A	0.94	Intronic	COL25A1	0	++++++−	6.0×10−6	0	0
rs11625623	14	51829096	G	0.23	Intergenic	PTGDR	15.9	+++++++	7.7×10−6	0	4
rs16901064	5	31422754	C	0.84	Intergenic	RNASEN	13.6	+++++++	7.8×10−6	2	2
rs6945846	7	114190152	C	0.20	Intergenic	FOXP2	71.8	+++++++	7.9×10−6	0	31
rs11629135	14	63982864	G	0.93	Intronic	MTHFD1	0	+++++++	8.6×10−6	0	10
rs9410016	9	137360523	G	0.41	Intergenic	C9orf62	−14.4	+++++++	9.7×10−6	0	5

^*in alphabetical order: AGES-Reykjavik, ARIC, ASPS, CHS, FHS, RS-I, and RS-II