Table 3.

Summary of meta-analyses results for the two top SNPs in discovery and replication cohorts.

Meta-analyses in the discovery cohorts and in the combined discovery and replication cohorts were conducted using the z-score method; Meta-analyses in the replication cohorts were conducted using both the z-score method and the inverse-variance weighted method.

		Meta-analysis in discovery cohorts			Meta-analysis in replication cohorts						Overall meta-analysis
SNP ID	Risk allele	Allele freq.	Direction of association*	P†	Allele freq.	Direction of association	Beta (SE) ‡	P	Phet¶	I2 (95% CI)	P†
rs3744028	C	0.18	+++++++	4.0×10−9	0.19	++	0.12 (0.02)	1.3×10−7 † 2.0×10−7 ‡	0.45	0% (0%–33%)	4.0×10−15
rs1055129	G	0.30	+++++−+	4.1×10−8	0.31	++	0.07 (0.02)	2.7×10−4 † 5.9×10−4 ‡	0.22	33% (0%–56%)	2.6×10−11

^*in cohort alphabetical order;

^†from z-score-based meta-analysis;

^‡from inverse-variance weighted meta-analysis;

^¶P value for Cochran’s Q-statistic for heterogeneity

CI: confidence interval