TABLE 2.
Selected Th cell-related genes up-regulated by IRF4 siRNA
An asterisk indicates main IFN-γ related genes.
| Unigene | Gene name | Ratios (siIRF4/siLuc) |
|
|---|---|---|---|
| Microarray | RT-PCR | ||
| Chemokines/cytokines and their receptors | |||
| Hs.72918 | CCL1 | 4.58 | |
| Hs.75498 | CCL20 | 2.14 | |
| Hs.1349 | CSF2 | 6.44 | |
| Hs.78913 | CX3CR1 | 7.53 | |
| Hs.89690 | CXCL3 | 2.00 | |
| Hs.77367 | CXCL9 | 10.41 | |
| Hs.632586 | CXCL10 | 6.55 | 17.91 |
| Hs.632592 | CXCL11 | 8.98 | |
| Hs.856 | IFNG* | 48.92 | 195.91 |
| Hs.158315 | IL18RAP* | 2.21 | |
| Hs.635723 | IL7R | 36.04 | |
| Hs.654459 | TNFRSF9 | 2.16 | |
| Hs.478275 | TNFSF10 | 3.11 | |
| Hs.525157 | TNFSF13B | 4.22 | |
| Hs.546295 | XCL1 | 28.24 | |
| Signal transduction/transcription factors | |||
| Hs.436061 | IRF1* | 2.80 | 3.86 |
| Hs.166120 | IRF7 | 3.25 | |
| Hs.1706 | IRF9* | 2.39 | |
| Hs.656213 | JAK2 | 1.90 | |
| Hs.498570 | PRKCQ | 4.10 | |
| Hs.708051 | STAT1* | 2.44 | 2.57 |
| Hs.530595 | STAT2* | 2.52 | 2.50 |
| Hs.272409 | T-bet* | 2.48 | 1.77 |
| Others | |||
| Hs.576612 | ENTPD1 | 2.39 | |
| Hs.369039 | PHF11 | 4.73 | 4.44 |
| Hs.130759 | PLSCR1 | 2.30 | |
| Hs.313 | SPP1* | 2.44 | |