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. 2011 Apr 4;286(24):21304–21314. doi: 10.1074/jbc.M110.211201

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Life span of abtm-1(RNAi) adults is increased in a partially daf-16–dependent manner. A, life span curves of abtm-1(RNAi) worms in wild type and daf-16(mu86) mutant backgrounds. The life span of abtm-1-depleted animals is significantly longer than control worms (p < 0.0001). Induction of abtm-1 RNAi also increases the life span of daf-16(mu86) mutants (p < 0.0001), but to a lesser extent (also see supplemental Table S1). B, abtm-1 RNAi induces localization of DAF-16 in the nucleus in some tissues in 70% of worms. Starved animals (first bar) were used as positive control, as they show strong nuclear DAF-16 localization.