Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Disruption of α/β disulfide linkage inhibits GP Ibα association with the GEMs. CHO cells expressing mutant GP Ibα (with the C484S and C485S mutants) were analyzed by sucrose density gradient fractionation. A substantial amount (∼60%) of GP Ibα was solubilized to the high density fraction, whereas GP Ibβ and GP IX remained associated (∼100%).
