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. 2011 Apr 27;286(24):21546–21554. doi: 10.1074/jbc.M110.203745

FIGURE 2.

FIGURE 2.

TWEAK assembles a proximal signaling complex containing FN14, TRAF2, and cIAP1. A, cells were treated with TWEAK (3 μg/ml) for the indicated amount of time and subjected to IP of FN14 followed by IB with antibodies to FN14, TRAF2, and cIAP1. B, cells were treated with TWEAK (3 μg/ml, 0.5 h) and subjected to IP of FN14 or TRAF2, followed by IB analysis of FN14 and TRAF2. C, cells were treated with TWEAK (3 μg/ml, 0.5 h) and subjected to IP of TRAF2 followed by IB of FN14, FADD, caspase-8, or TRAF2. D, cells were treated with TWEAK (3 μg/ml) for the indicated time and subjected to IB analysis of TRAF2 and cIAP1. The asterisk indicates a nonspecific band.