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Model of regulation of TTP expression by CK2. The p38 MAPK/MK2 signaling pathway can induce phosphorylation (P) of TTP, which leads to proteasomal degradation of TTP protein. However, when CK2 is activated by TGF-β stimulation, it can activate MKP-1, which in turn inhibits the p38 MAPK/MK2 pathway by dephosphorylation of p38 MAPK, thereby protecting the TTP protein from proteasomal degradation.
