FIGURE 2.

Influence of heparin on adherence to and internalization into human keratinocytes. A, chromogenic plasminogen binding assay of GAS M49 with and without heparin. The data represent the mean values ± S.D. from twenty independent experiments. B, influence of heparin on the S. pyogenes M49 attachment to and (C) internalization into HaCaT cells in the absence (none) or presence (Pg) of human plasminogen/plasmin. The percentage of attached or internalized bacteria in the absence or presence of plasminogen/plasmin was used as a control. The data represent the mean values ± S.D. from five independent experiments. Only significant differences are indicated.