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Proliferation and immunoglobulin synthesis in vitro by naive B cells from C76R/TACI+/− transgenic mice. Proliferation (A) and IgG1 synthesis (B) in response to APRIL are shown. B cells were stimulated with anti-CD40 plus IL-4 as a control for proliferation and IgG1 production (n = 5-9 mice per group). The Mann-Whitney test was used to calculate significance. MED, Medium alone. *P < .05, **P < .01, and ***P < .001.
