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. 2011 Feb 3;3:1–13. doi: 10.4137/BIC.S6111

Table SB.

Combined effects of N-acetyltransferase polymorphisms and cigarette smoking on PCa risk.

N-acetyltransferase status Unadjusted OR (95% CI)a
#Cases||#Ctrlsc
Adjusted OR (95% CI)b


Non-smokers Ever-smokers Non-smokers Ever-smokers
NAT2 Rapid alleles 1.00 (Reference)
5||5
2.04 (0.54–7.62)
57||28
1.00 (Reference) 1.46 (0.33–6.45)
≥1 NAT2 Slow allele(s) 0.71 (0.13–3.87)
5||7
3.19 (0.84–12.10)
67||21
0.33 (0.05–2.24) 2.06 (0.45– 9.42)
P-value for interaction 0.1445

Notes:

a

Associations were determined using multivariate logistic regression models to estimate the risk of developing PCa using Inheritance of two NAT2 rapid alleles and non-smokers as the referent category;

b

Risk estimates adjusted for age and West African Ancestry, modeled as continuous variables;

c

The analysis was restricted to study participants who had available smoking and N-acetyltransferase genotype status analysis.