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. 2011 Feb 3;3:1–13. doi: 10.4137/BIC.S6111

Table 2.

Functional consequences of N-acetyltransferase alleles.

Gene Allele Nucleotide change Amino acid change Deduced acetylator status
NAT1a *4 Reference Reference Reference
*3 C1095A (rs15561)
*10 T1088A (rs1057126), C1095A Rapid
*11 G445A (rs4987076), C1095A Val149Ile
*14A G560A (rs4986782), T1088A, C1095A Arg187Gln Slow
*14B G560A Arg187Gln Slow
*15 C559T (rs5030839) Arg187Stop Slow
*17 C190T (rs56379106) Arg64Trp Slow
*19 C97T (rs56318881) Arg33Stop Slow
*22 A752T (rs56172717) Asp251Val Slow
NAT2b
*4 None Reference Rapid
*5A T341C (rs1801280), C481T (rs1799929) Ile114Thr, Leu161Leu Slow
*5B T341C, C481T, A803G (rs1208) Ile114Thr, Leu161Leu, Lys268Arg Slow
*5C T341C, A803G Ile114Thr, Lys268Arg Slow
*5D T341C Ile114Thr Slow
*5E T341C, G590A (rs1799930) Ile114Thr, Arg197Gln Slow
*5G C282T (rs1041983), T341C, C481T, A803G Tyr94Tyr, Leu161Leu Slow
*5J C282T, T341C, G590A Tyr94Tyr, Ile114Thr, Slow
*6A C282T, G590A Tyr94Tyr, Arg197Gln Slow
*6B G590A Arg197Gln Slow
*6C C282T, G590A, A803G Tyr94Tyr, Arg197Gln, Lys268Gln Slow
*6E C481T, G590A Leu161Leu, Arg197Gln Slow
*7A G857A (rs1799931) Gly286Arg Slow
*7B C282T, G857A Tyr94Tyr, Gly286Glu Slow
*7C C282T, A803G, G857A Tyr94Tyr, Gly286Glu, Lys268Gln Slow
*11A C481T Leu161Leu Rapid
*12A A803G Lys268Arg Rapid
*12B C282T, A803G Tyr94Tyr, Lys268Arg Rapid
*12C C481T, A803G Leu161Leu, Lys268Arg Rapid
*13A C282T Tyr94Tyr Rapid
*14A G191A (rs1801279) Arg64Gln, Tyr94Tyr Slow
*14B G191A, C282T Arg64Gln Slow
*14C G191A, T341C, C481T, A803G Arg64Gln, Ile114Thr, Leu161Leu, Lys268Arg Slow
*14D G191A, C282T, T341C, G590A Arg64Gln, Tyr94Tyr, Arg197Gln Slow
*14E G191A, A803G Arg64Gln, Lys268Arg Slow
*14F G191A, T341C, A803G Arg64Gln, Ile114Thr Lys268Arg Slow
*14G G191A, C282T, A803G Arg64Gln, Tyr94Tyr, Lys268Arg Slow