. 2011 Feb 3;3:1–13. doi: 10.4137/BIC.S6111

Table 2.

Functional consequences of N-acetyltransferase alleles.

Gene	Allele	Nucleotide change	Amino acid change	Deduced acetylator status
*NAT1*^a	*4	Reference	Reference	Reference
	*3	C¹⁰⁹⁵A (rs15561)
	*10	T¹⁰⁸⁸A (rs1057126), C¹⁰⁹⁵A		Rapid
	*11	G⁴⁴⁵A (rs4987076), C¹⁰⁹⁵A	Val¹⁴⁹Ile
	*14A	G⁵⁶⁰A (rs4986782), T¹⁰⁸⁸A, C¹⁰⁹⁵A	Arg¹⁸⁷Gln	Slow
	*14B	G⁵⁶⁰A	Arg¹⁸⁷Gln	Slow
	*15	C⁵⁵⁹T (rs5030839)	Arg¹⁸⁷Stop	Slow
	*17	C¹⁹⁰T (rs56379106)	Arg⁶⁴Trp	Slow
	*19	C⁹⁷T (rs56318881)	Arg³³Stop	Slow
	*22	A⁷⁵²T (rs56172717)	Asp²⁵¹Val	Slow
*NAT2*^b
	*4	None	Reference	Rapid
	*5A	T³⁴¹C (rs1801280), C⁴⁸¹T (rs1799929)	Ile¹¹⁴Thr, Leu¹⁶¹Leu	Slow
	*5B	T³⁴¹C, C⁴⁸¹T, A⁸⁰³G (rs1208)	Ile¹¹⁴Thr, Leu¹⁶¹Leu, Lys²⁶⁸Arg	Slow
	*5C	T³⁴¹C, A⁸⁰³G	Ile¹¹⁴Thr, Lys²⁶⁸Arg	Slow
	*5D	T³⁴¹C	Ile¹¹⁴Thr	Slow
	*5E	T³⁴¹C, G⁵⁹⁰A (rs1799930)	Ile¹¹⁴Thr, Arg¹⁹⁷Gln	Slow
	*5G	C²⁸²T (rs1041983), T³⁴¹C, C⁴⁸¹T, A⁸⁰³G	Tyr⁹⁴Tyr, Leu¹⁶¹Leu	Slow
	*5J	C²⁸²T, T³⁴¹C, G⁵⁹⁰A	Tyr⁹⁴Tyr, Ile¹¹⁴Thr,	Slow
	*6A	C²⁸²T, G⁵⁹⁰A	Tyr⁹⁴Tyr, Arg¹⁹⁷Gln	Slow
	*6B	G⁵⁹⁰A	Arg¹⁹⁷Gln	Slow
	*6C	C²⁸²T, G⁵⁹⁰A, A⁸⁰³G	Tyr⁹⁴Tyr, Arg¹⁹⁷Gln, Lys²⁶⁸Gln	Slow
	*6E	C⁴⁸¹T, G⁵⁹⁰A	Leu¹⁶¹Leu, Arg¹⁹⁷Gln	Slow
	*7A	G⁸⁵⁷A (rs1799931)	Gly²⁸⁶Arg	Slow
	*7B	C²⁸²T, G⁸⁵⁷A	Tyr⁹⁴Tyr, Gly²⁸⁶Glu	Slow
	*7C	C²⁸²T, A⁸⁰³G, G⁸⁵⁷A	Tyr⁹⁴Tyr, Gly²⁸⁶Glu, Lys²⁶⁸Gln	Slow
	*11A	C⁴⁸¹T	Leu¹⁶¹Leu	Rapid
	*12A	A⁸⁰³G	Lys²⁶⁸Arg	Rapid
	*12B	C²⁸²T, A⁸⁰³G	Tyr⁹⁴Tyr, Lys²⁶⁸Arg	Rapid
	*12C	C⁴⁸¹T, A⁸⁰³G	Leu¹⁶¹Leu, Lys²⁶⁸Arg	Rapid
	*13A	C²⁸²T	Tyr⁹⁴Tyr	Rapid
	*14A	G¹⁹¹A (rs1801279)	Arg⁶⁴Gln, Tyr⁹⁴Tyr	Slow
	*14B	G¹⁹¹A, C²⁸²T	Arg⁶⁴Gln	Slow
	*14C	G¹⁹¹A, T³⁴¹C, C⁴⁸¹T, A⁸⁰³G	Arg⁶⁴Gln, Ile¹¹⁴Thr, Leu¹⁶¹Leu, Lys²⁶⁸Arg	Slow
	*14D	G¹⁹¹A, C²⁸²T, T³⁴¹C, G⁵⁹⁰A	Arg⁶⁴Gln, Tyr⁹⁴Tyr, Arg¹⁹⁷Gln	Slow
	*14E	G¹⁹¹A, A⁸⁰³G	Arg⁶⁴Gln, Lys²⁶⁸Arg	Slow
	*14F	G¹⁹¹A, T³⁴¹C, A^803G	Arg⁶⁴Gln, Ile¹¹⁴Thr Lys²⁶⁸Arg	Slow
	*14G	G¹⁹¹A, C²⁸²T, A⁸⁰³G	Arg⁶⁴Gln, Tyr⁹⁴Tyr, Lys²⁶⁸Arg	Slow

Notes:

NAT1, N-acetyltransferase 1, http://louisville.edu/medschool/pharmacology/consensus-human-arylamine-n-acetyltransferase-gene-nomenclature/nat_pdf_files/Human_NAT1_alleles.pdf;

NAT2, N-acetyltransferase 2, http://louisville.edu/medschool/pharmacology/consensus-humanarylamine-n-acetyltransferase-gene-nomenclature/nat_pdf_files/Human_NAT2_alleles.pdf.