Table SA.

Effect modification of NAT1 and NAT2 in relation to PCa susceptibility.

#NAT1*10 alleles	#Slow NAT2 alleles	Cases (%)|| controls (%)	Estimated OR (95% CI)a	Estimated OR (95% CI)b	P-value for Interaction
0 or 1	0 NAT2 Slow	12 (7.1) || 43 (9.4)	1.00 (Referent)	1.00 (Referent)	0.2897
0 or 1	1 NAT2 Slow	58 (34.3) || 158 (34.8)	1.32 (0.65–2.67)	1.01 (0.46–2.22)
0 or 1	2 NAT2 Slow	63 (37.3) || 132 (29.1)	1.71 (0.84–3.47)	1.63 (0.74–3.58)
2	0 NAT2 Slow	3 (1.8) || 18 (4.0)	0.60 (0.15–2.37)	0.73 (0.17–3.13)
2	1 NAT2 Slow	22 (13.0) || 54 (11.9)	1.46 (0.65–3.28)	1.18 (0.48–2.90)
2	2 NAT2 Slow	11 (6.5) || 49 (10.8)	0.80 (0.32–2.01)	0.75 (0.28–2.04)
0 or 1	0 NAT2 Rapid	63 (37.3) || 132 (29.1)	1.00 (Referent)	1.00 (Referent)	0.2156
0 or 1	1 NAT2 Rapid	58 (34.3) || 158 (34.8)	0.77 (0.50–1.18)	0.62 (0.38–1.02)
0 or 1	2 NAT2 Rapid	12 (7.1) || 43 (9.4)	0.58 (0.29–1.18)	0.61 (0.28–1.34)
2	0 NAT2 Rapid	11 (6.5) || 49 (10.8)	0.47 (0.23–0.97)	0.46 (0.21–1.01)
2	1 NAT2 Rapid	22 (13.0) || 54 (11.9)	0.85 (0.48–1.52)	0.72 (0.38–1.40)
2	2 NAT2 Rapid	3 (1.8) || 18 (4.0)	0.35 (0.10–1.23)	0.45 (0.12–1.68)

Notes:

^aAssociations were determined using univariate logistic regression models to estimate the risk of developing PCa. 151 subjects had missing genotype data for NAT1 and/or NAT2;

^bRisk estimates adjusted for age (continuous variable) and West African Ancestry (WAA; continuous variable).