Table 2.
Percentages of individuals predicted to be cured using drugs with and without artemisinins according to the dosing regimens detailed in Table 1, parasite clearance times, and periods of chemoprophylaxisa
| Output | Drug |
|||||
|---|---|---|---|---|---|---|
| Artemether | Artesunate | Chloroquine (plus artesunate) | Lumefantrine (plus artesunate, artemether) | Mefloquine (plus artesunate) | Piperaquine (plus DHA) | |
| Outputs with no variation in default PK/PD values | ||||||
| % Cured | 0 | 0 | 100 (100) | 100 (100, 100) | 100 (100) | 100 (100) |
| PCT (days) with P0 = 1010 | 0 | 0 | 4 (2) | 3 (2, 1) | 3 (2) | 3 (2) |
| PCT (days) with P0 = 1011 | 0 | 0 | 6 (3) | 4 (2, 2) | 4 (2) | 4 (2) |
| PCT (days) with P0 = 1012 | 0 | 0 | 7 (4) | 5 (3, 2) | 5 (3) | 5 (3) |
| PoC (days) | 9 | 9 | 87 | 41 | 80 | 57 |
| Outputs with variation added to default PK/PD values, using a CV of 0.3 | ||||||
| Apparent cure rate after 28 days (%) | 0 | 0 | 92 (96) | 96 (98, 99) | 97 (98) | 96 (97) |
| Apparent cure rate after 63 days (%) | 0 | 0 | 91 (93) | 90 (93, 96) | 97 (99) | 91 (92) |
| True cure rate (%) | 0 | 0 | 85 (88) | 90 (93, 95) | 96 (97) | 90 (91) |
| Mean PCT (days) ± SD | 6.4 ± 4.5 (3.4 ± 2.64) | 4.98 ± 3.915 (2.76 ± 2.1, 1.98 ± 0.65) | 5.3 ± 4.7 (2.9 ± 2.7) | 5.3 ± 3.95 (3.4 ± 2.5) | ||
| Mean PoC (5th centile) (days) | 52 | 31 | 59 | 40 | ||
a
Note that the artemisinins have no effect on PoC because of their short half-lives, so PoC values are identical for all ACTs and their partner drug monotherapies.