Table 6.
Effects of low day 7 serum levels (<15th centile) on predicted outcomes of treatments
| Drug | Outputa |
||||
|---|---|---|---|---|---|
| OR | Sensitivity | Specificity | AUROC | PAR% | |
| Chloroquine | 2.153 (1.883-2.462) | 0.248 (0.229-0.268) | 0.867 (0.864-0.870) | 0.632 (0.617-0.647) | 11.584 |
| Chloroquine plus artesunate | 2.086 (1.805-2.411) | 0.248 (0.227-0.271) | 0.863 (0.860-0.866) | 0.627 (0.610-0.643) | 11.567 |
| Lumefantrine | 1.934 (1.654-2.262) | 0.240 (0.216-0.265) | 0.860 (0.857-0.863) | 0.615 (0.596-0.633) | 10.532 |
| Lumefantrine plus artesunate | 1.919 (1.605-2.295) | 0.242 (0.214-0.273) | 0.857 (0.855-0.860) | 0.603 (0.582-0.624) | 10.839 |
| Lumefantrine plus artemether | 1.354 (1.067-1.719) | 0.190 (0.158-0.227) | 0.852 (0.850-0.854) | 0.557 (0.530-0.583) | 4.762 |
| Mefloquine | 1.393 (1.104-1.759) | 0.195 (0.162-0.231) | 0.852 (0.851-0.854) | 0.554 (0.528-0.580) | 5.242 |
| Mefloquine plus artesunate | 1.243 (0.955-1.619) | 0.179 (0.144-0.218) | 0.851 (0.850-0.853) | 0.538 (0.509-0.567) | 3.361 |
| Piperaquine | 2.557 (2.199-2.973) | 0.286 (0.260-0.312) | 0.865 (0.862-0.868) | 0.646 (0.628-0.665) | 15.949 |
| Piperaquine plus DHA | 2.618 (2.236-3.066) | 0.293 (0.265-0.321) | 0.864 (0.861-0.866) | 0.645 (0.626-0.664) | 16.780 |
a
OR, odds ratio; AUROC, area under the ROC curve; PAR%, population attributable risk percentage. Data are means with 95% confidence intervals.