Table 1.
In vitro interactions of DAMB and Mycograb C28Y variant for 5 C. albicans isolates in two trialsa
| Trial no. | C. albicans strain | Agent | MIC (μg/ml) |
FIC | FICI | Outcome | |
|---|---|---|---|---|---|---|---|
| Agent alone | Two agents in combination | ||||||
| 1 | ATCC 24433 | DAMB | 0.5 | 0.125 | 0.25 | 0.258 | Synergy |
| Myc-C28Y | >128 | 4 | 0.008 | ||||
| ATCC 36082 | DAMB | 0.5 | 0.125 | 0.25 | 0.252 | Synergy | |
| Myc-C28Y | >128 | 1 | 0.002 | ||||
| ATCC 90028 | DAMB | 0.5 | 0.125 | 0.25 | 0.258 | Synergy | |
| Myc-C28Y | >128 | 4 | 0.008 | ||||
| ATCC 90029 | DAMB | 0.5 | 0.125 | 0.25 | 0.258 | Synergy | |
| Myc-C28Y | >128 | 4 | 0.008 | ||||
| ATCC 64548 | DAMB | 0.5 | 0.125 | 0.25 | 0.258 | Synergy | |
| Myc-C28Y | >128 | 4 | 0.008 | ||||
| 2 | ATCC 24433 | DAMB | 1 | 0.125 | 0.125 | 0.141 | Synergy |
| Myc-C28Y | >32 | 8 | 0.016 | ||||
| ATCC 36082 | DAMB | 0.5 | 0.125 | 0.25 | 0.266 | Synergy | |
| Myc-C28Y | >32 | 8 | 0.016 | ||||
| ATCC 90028 | DAMB | 0.5 | 0.125 | 0.25 | 0.258 | Synergy | |
| Myc-C28Y | >32 | 4 | 0.008 | ||||
| ATCC 90029 | DAMB | 0.5 | 0.125 | 0.25 | 0.258 | Synergy | |
| Myc-C28Y | >32 | 4 | 0.008 | ||||
| ATCC 64548 | DAMB | 0.5 | 0.125 | 0.25 | 0.258 | Synergy | |
| Myc-C28Y | >32 | 4 | 0.008 | ||||
a
DAMB monotherapy was without vehicle. The FICs for the Myc-C28Y variant were calculated using an MIC of 512 μg/ml for the antibody fragment when tested alone.