Fig. 1.

Caspofungin improves survival and reduces median lung fungal burden and in neutropenic but not corticosteroid-immunosuppressed mice with invasive pulmonary mucormycosis. (a and b) Survival curves are presented for neutropenic (a) and corticosteroid-immunosuppressed (b) animals. Each group contained ≥15 mice. *, P < 0.05 by Mantel-Cox log-rank test. (c and d) Lung fungal burden was assessed at day +7 after infection or at the time of euthanization of experimentally infected neutropenic (c) or corticosteroid-immunosuppressed (d) animals. Each datum point represents the mean R. oryzae conidial equivalent (CE) concentration of DNA per lung from a single mouse measured in duplicate using a quantitative real-time PCR assay in relation to a 6-point standard curve. Solid bars represent the median fungal burden values. P values were determined by analysis of variance (ANOVA) with Dunn's correction for multiple comparisons.