Table 2.
Bacterial killing at 48 h and occurrence of reduced vancomycin susceptibility during CIV
| ƒAUC24/MICa | Total AUC24/MIC equivalenta,b | HCA and CA MRSA |
HCA MRSA |
CA MRSA |
|||
|---|---|---|---|---|---|---|---|
| BK48 (log10 CFU/ml)c | RVSd at 48 h | BK48 (log10 CFU/ml) | RVS at 48 h | BK48 (log10 CFU/ml) | RVS at 48 h | ||
| 30–60 | 60–120 | 2.2 (−1.4, 3.4) | 10/24 (42) | 1.8 (−1.7, 3.9) | 10/18 (56) | 2.7 (2.1, 2.9) | 0/6 (0) |
| 120 | 240 | 2.3 (1.3, 3.0) | 6/27 (22) | 2.2 (1.4, 2.7) | 4/14 (29) | 2.7 (1.3, 4.0) | 2/13 (15) |
| 240 | 480 | 3.7 (3.1, 4.0) | 2/21 (10) | 3.7 (3.2, 4.0) | 1/10 (10) | 3.8 (2.9, 4.0) | 1/11 (9) |
| 480–960 | 960–1,920 | 3.8 (2.9, 4.0) | 0/18 (0) | 3.8 (3.1, 4.0) | 0/6 (0) | 3.8 (2.9, 4.0) | 0/12 (0) |
a
Based on broth microdilution MIC.
b
Equivalent total AUC24/MIC based on 50% protein binding in serum.
c
BK48 data are presented as median (interquartile range) values.
d
The number of isolates with reduced vancomycin susceptibility (RVS)/total (%) is shown.