FIG. 2.

Bacterial content in the lungs and spleen in rabbits after 2 days of treatment with ceftriaxone (CRO) equivalent to 1 g given intravenously (IV) daily or ceftaroline (CPT) equivalent to 600 mg IV twice daily in the pneumonia model. The three strains used in Fig. 1 were used here. Values are means plus standard deviations (SDs) (error bars). The lower limit of detection was 1 log CFU/g. Values that are significantly different are indicated by the horizontal lines and asterisks as follows: *, P < 0.05; ***, P < 0.001. Abbreviations: PSSP, penicillin-susceptible S. pneumoniae, PISP, penicillin-intermediate S. pneumoniae; PRSP, penicillin-resistant S. pneumoniae.