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Comparative efficacies of various doses of ceftaroline and NXL104 at 24 h compared with 0-h controls for E. coli 356 (CPT-NXL104 MIC < 0.015 μg/ml) (A), K. pneumoniae 401 (0.06 μg/ml) (B), and E. coli 361 (0.5 μg/ml) (C) in immunocompetent (solid bars)- and neutropenic (patterned bars)-thigh-infection models. Each value is the mean ± standard deviation for five or six infected thighs. Asterisks indicate statistically significant differences at a given dose (P < 0.05).
