Table 1.
Observed-predicted regression equations for the system outputs after the Bayesian estimation step for the murine model
| System output | Regression resulta |
||
|---|---|---|---|
| Slope | Intercept | r2 | |
| Meropenem plasma concn | 0.980 | +0.164 | 0.995 |
| Meropenem ELF concn | 0.960 | +0.025 | 0.997 |
| Total bacterial counts | 0.883 | +0.638 | 0.914 |
| Meropenem-resistant bacterial counts | 0.776 | +0.464 | 0.801 |
a
Observed = slope × output + intercept, where output is one of meropenem concentration in plasma or ELF or total bacterial population counts or drug-resistant population counts.