Table 3.
Parameter estimates from the population pharmacokinetic analysis from 39 patients with ventilator-associated pneumonia
| Parametera | Vc (liters) | CL (liters/h) | K12 (h−1) | K21 (h−1) | K13 (h−1) | K31 (h−1) | VELF (liters) |
|---|---|---|---|---|---|---|---|
| Mean | 12.6 | 15.2 | 8.32 | 14.1 | 10.1 | 14.2 | 30.4 |
| Median | 6.68 | 13.5 | 3.15 | 11.2 | 8.02 | 15.4 | 24.2 |
| SD | 13.3 | 9.71 | 9.82 | 11.8 | 8.63 | 11.4 | 25.2 |
a
Vc, volume of the central compartment; CL, plasma clearance; K12, K21, K13, K31, first order intercompartmental transfer rate constants; VELF, volume of the ELF compartment.