Table 2.

Means and standard deviations for parameter values from mathematical model for wild-type and isogenic mutants

Parameter	Wild type		Heterozygous mutantb		Homozygous mutantsc
	Mean	SDd	Mean	SD	Mean	SD
Ka (h−1)	13.23	5.21	14.11	8.35	23.22	4.28
SCL (liter/h)	0.0005	0.0002	0.0004	0.0003	0.0005	0.0003
Vc (liter)	0.0029	0.0002	0.006	0.006	0.0079	0.004
Kcp (h−1)	5.20	5.36	12.22	10.98	5.00	11.01
Kpc (h−1)	33.15	6.66	25.78	9.83	27.98	10.80
Kck (h−1)	31.82	5.14	24.41	8.36	17.71	5.34
Kkc (h−1)	19.46	7.71	14.71	7.96	25.7	5.41
Vkid (liter)	0.007	0.0053	0.01	0.008	0.006	0.002
Kgmax (log10 CFU/g/h)	0.11	0.038	0.14	0.043	0.133	0.028
Hg	3.70	2.00	4.23	1.90	4.38	2.50
C50g (mg/liter)	1.54	0.26	21.74	12.20	52.66	33.36
POPMAX (CFU/g)	1,230,960	2,003,520	231,528	225,722	179,371	108,849
Kkmax (log10 CFU/g/h)	0.118	0.028	0.128	0.05	0.15	0.044
Hk	3.08	1.27	3.65	2.34	4.66	2.66
C50k (mg/liter)	2.01	1.14	28.81	14.39	42.06	26.57
Initial conditiona (CFU/g)	1,262	821.6	74.01	21.75	134.08	166.36

^aInitial condition, fungal burden at the time of systemic drug administration.

^bThe heterozygous mutant is A15.

^cThe homozygous mutants include 36S, 22S, and 22S.

^dSD, standard deviation.