Table 1.
Geometric mean and geometric mean ratio (90% CI) of efavirenz steady-state pharmacokinetic parameter estimates in the absence and presence of efavirenz in healthy volunteersa
| Pharmacokinetic parameter | Geometric mean (90% CI) |
Geometric mean ratio (EFV-RIF/EFV) (90% CI) | |
|---|---|---|---|
| EFV alone (n = 11) | EFV-RIF (n = 11) | ||
| Tmax (h) | 2.46 (2.10, 2.89) | 2.30 (1.56, 3.39) | 0.99 (0.76, 1.29) |
| Cmax (ng/ml) | 4,571 (652, 5,721) | 3,882 (3,034, 4,966) | 0.84 (0.71, 1.00) |
| C24h (ng/ml) | 1,766 (1,262, 2,472) | 1,435 (1,026, 2,009) | 0.81 (0.73, 0.89) |
| AUC0-24 (ng·h/ml) | 59,429 (45,604, 77,466) | 48,865 (36,475, 65,464) | 0.82 (0.72, 0.92) |
| CL/F (ml/h) | 2,958 (1,380, 6,339) | 4,656 (3,112, 6,966) | 1.55 (1.15, 2.11) |
a
CI, confidence interval; EFV, efavirenz; RIF, rifampin; n, number of subjects; Cmax, peak concentration; Tmax, time to Cmax; C24h, 24-h-postdose concentration; AUC0-24, total area under the curve from time zero to 24 h; CL/F, apparent oral clearance.