Table 1.
Inhibition of chloroquine (0.1 μM) net transcellular transport in double-transfected MDCK-OCT2-MATE1 cells by various compounds
| Compound | CAS registry no. | Concn (μM) | Net chloroquine transport (%)a |
|
|---|---|---|---|---|
| Mean | SD | |||
| None | 100 | 6.6 | ||
| Metformin | 1115-70-4 | 10 | 99.5 | 11 |
| 100 | 92.9 | 17 | ||
| Levofloxacin | 100986-85-4 | 10 | 82.3 | 20 |
| 100 | 83.5 | 18 | ||
| Lamivudine | 134678-17-4 | 10 | 90.0 | 9.0 |
| 100 | 94.5 | 9.2 | ||
| Primaquine | 63-45-6 | 10 | 88.5 | 9.7 |
| 100 | 74.6 | 21 | ||
| Verapamil | 23313-68-0 | 10 | 96.8 | 15 |
| 100 | 89.4 | 17 | ||
| Amitriptyline | 549-18-8 | 10 | 87.8 | 5.1 |
| 100 | 68.2** | 7.1 | ||
| Trimethoprim | 738-70-5 | 10 | 55.8*** | 23 |
| 100 | 12.5*** | 6.0 | ||
a
**, P < 0.01; ***, P < 0.001.