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Statistical comparisons of DTG pharmacokinetics with or without the coadministration of either ETR/LPV/RTV or ETR/DRV/RTV
| Plasma DTG PK parameter | GLS mean ratio (90% CI) |
|
|---|---|---|
| ETR/LPV/RTV + DTG vs DTG in cohort 1 (n = 8) | ETR/DRV/RTV + DTG vs DTG in cohort 2 (n = 9) | |
| AUC0-τ | 1.11 (1.02–1.20) | 0.750 (0.691–0.814) |
| Cmax | 1.07 (1.02–1.13) | 0.882 (0.781–0.997) |
| Cτ | 1.28 (1.13–1.45) | 0.629 (0.523–0.758) |
| CL/F | 0.905 (0.832–0.984) | 1.33 (1.23–1.45) |
| t1/2 | 1.36 (1.20–1.54) | 0.993 (0.891–1.11) |
