Table 1.
In vitro activity of BVM against different viruses in single-cycle infectivity assay
| Virus | BVM EC50 (μM)a |
|---|---|
| NL4-3 | 0.039 ± 0.005 |
| NL4-3(Q6A) | 0.031 ± 0.009 |
| NL4-3(V7A) | >17.1b |
| NL4-3(T8A) | 0.038 ± 0.009 |
| NL/MJ4 | >17.1b |
| NL/MJ4(A7V) | 3.261 ± 1.739 |
| NL/MJ4(N8T) | >17.1b |
| NL/MJ4(AN78VT) | 0.125 ± 0.053 |
a
Antiviral activity was determined after infection of TZM-bl indicator cells with VSV-G-pseudotyped HIV-1 as described in Materials and Methods. Values represent means ± standard deviations for two independent experiments performed in triplicate.
b
The highest drug concentration tested in this study.