Table 2.
Localization of fungi, total infection rate, and frequency of subungual abscesses in experimental evaluation of drug efficacy
| Treatment and locatione | Infection ratea (%) |
Total infection rateb (%) | Appearance rate of subungual abscessesc (%) |
Total appearance rate of subungual abscessesd (%) | ||
|---|---|---|---|---|---|---|
| Dorsal side | Ventral side | Dorsal side | Ventral side | |||
| None | ||||||
| D | 0.0 (0.00)f | 65.2 (1.83) | 66.7 | 0.0 | 47.8 | 58.3 |
| M | 26.1 (0.54) | 34.8 (0.86) | 21.7 | 43.5 | ||
| P | 12.5 (0.13) | 4.2 (0.13) | 4.2 | 4.2 | ||
| 8% Ciclopirox nail lacquer | ||||||
| D | 4.8 (0.13) | 33.3 (0.9) | 47.6 | 4.8 | 33.3 | 38.1 |
| M | 19 (0.29) | 19 (0.35) | 9.5 | 14.3 | ||
| P | 14.3 (0.13) | 9.5 (0.08) | 4.8 | 0.0 | ||
| 5% Amorolfine nail lacquer | ||||||
| D | 4.3 (0.13) | 26.1 (0.67) | 43.5 | 4.3 | 26.1 | 39.1 |
| M | 8.7 (0.17) | 30.4 (0.63) | 4.3 | 30.4 | ||
| P | 13.6 (0.18) | 4.5 (0.13) | 0.0 | 0.0 | ||
Infection rate was determined with the formula (number of histologically fungus-positive nails in each region/number of nails tested in each region) × 100.
Total infection rate was determined with the formula (number of histologically fungus-positive nails/number of nails tested) × 100.
Localization of appearance rate was determined with the formula (number of nails with subungual abscesses in each region/number of nails tested in each region) × 100.
Total appearance rate was determined with the formula (number of nails with subungual abscesses/number of nails tested) × 100.
D, distal; M, middle; P, proximal.
Numbers in parentheses are averages of infection intensity grades in each region.