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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2011 Jul;70(7):578–587. doi: 10.1097/NEN.0b013e3182204414

Figure 1.

Figure 1

Serial sections from the brainstem in a case of progressive supranuclear palsy (PSP). (A-D) Colocalization of ppRbser807 (A, C) and AT8 labeling of hyperphosphorylated tau (B, D) in PSP tangles. Higher magnification of boxes from (A) and (B) are shown in C and D, respectively. Glial tau pathology (arrowheads in D) is demonstrated with the AT8 antibody. (E) pRb612 is also localized to a population of PSP tangles and neurites. (F) Phosphorylated minichromosome maintenance 2 (pMcm2), another cell cycle marker, is specifically localized to PSP tangles and neurites. (G, H) Both ppRbser807 (G) and pMcm2 (H) are present in the same neurons seen in adjacent serial sections. Asterisks denote landmark vessels and arrows identify the same neurons across serial sections. Scale bars = 50 μm.