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IgM response in mice immunized with pneumococcal PS-CRM197 conjugate vaccine with PBS or 100 μg of OMPC. (A) Week 2. (B) Week 3. (C) Week 4. (D) Week 6. Comparison of results for OMPC recipients and PBS recipients is shown as follows: *, P < 0.05; +, P ≤ 0.01; #, P ≤ 0.001. n = 5 mice per group; the experiment was repeated three times with similar results. Error bars show standard deviations.
