Table 5.
Percentage lymphocyte subset concentration by age from peripheral blood from healthy children in Cameroon
| Subset | Total no. of samples | Median % lymphocyte concn (10th and 90th percentiles) for the indicated age groupa |
P |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cord blood | 0–3 mo | 3–6 mo | 6–12 mo | 12–24 mo | 2–6 yr | Ageb | Sex | ||
| CD3 | 352 | 65 (53–73) | 60 (44–75) | 52 (44–66) | 59 (49–72) | 57 (39–74) | 59 (50–73) | NS | 0.17 |
| CD4 | 352 | 44 (34–57) | 41 (32–57) | 37 (25–51) | 38 (28–48) | 34 (21–46) | 35 (26–44) | NS | 0.71 |
| CD8 | 352 | 17 (11–30) | 16 (10–27) | 14 (10–21) | 20 (13–27) | 18 (11–30) | 20 (14–30) | NS | 0.02 |
| T4/T8 | 351 | 3 (2–5) | 3 (2–5) | 3 (2–5) | 3 (2–4) | 2 (1–4) | 2 (2–3) | NS | 0.04 |
| CD19 | 349 | 16 (9–23) | 27 (11–43) | 34 (20–46) | 30 (18–41) | 29 (12–50) | 25 (17–38) | NS | 0.63 |
| NK | 349 | 16 (6–28) | 10 (5–15) | 8 (6–33) | 8 (4–13) | 8 (4–26) | 8 (4–25) | NS | 0.41 |
| 4/DR/38 | 338 | 2 (1–6) | 3 (2–5) | 3 (2–8) | 3 (2–8) | 4 (3–8) | 4 (2–7) | NS | 0.88 |
| 4/DR | 337 | 2 (1–6) | 4 (3–7) | 4 (3–11) | 4 (3–9) | 5 (3–11) | 5 (3–9) | NS | 0.83 |
| 4/38 | 344 | 98 (95–99) | 94 (89–97) | 92 (77–96) | 92 (83–95) | 86 (71–90) | 79 (71–84) | NS | 0.44 |
| 8/DR/38 | 340 | 1 (1–4) | 5 (2–32) | 7 (2–29) | 10 (6–32) | 10 (6–33) | 9 (6–23) | NS | 0.75 |
| 8/DR | 343 | 1 (1–7) | 6 (2–32) | 8 (2–29) | 11 (6–32) | 11 (6–34) | 10 (8–33) | NS | 0.66 |
| 8/38 | 345 | 95 (89–98) | 97 (81–99) | 95 (77–97) | 93 (77–99) | 84 (56–95) | 79 (54–88) | NS | 0.85 |
| 3/4/RO | 333 | 10 (3–32) | 11 (5–19) | 12 (7–23) | 12 (9–25) | 16 (11–33) | 19 (15–30) | NS | 0.22 |
| 3/4/RA | 334 | 41 (19–59) | 41 (20–59) | 36 (16–58) | 38 (20–58) | 29 (16–53) | 27 (18–40) | NS | 0.24 |
| 4/RA | 342 | 90 (84–96) | 85 (72–90) | 81 (52–91) | 80 (68–87) | 67 (50–83) | 64 (54–76) | NS | 0.56 |
| 4/RO | 342 | 10 (4–16) | 15 (10–28) | 19 (9–48) | 20 (13–32) | 33 (17–50) | 36 (24–46 | NS | 0.56 |
| 3/8/RO | 323 | 3 (1–6) | 3 (1–12) | 4 (1–14) | 5 (3–19) | 5 (3–13) | 7 (4–16) | NS | 0.7 |
| 3/8/RA | 300 | 22 (11–40) | 20 (14–49) | 20 (15–25) | 22 (14–54) | 20 (15–69) | 21 (16–49) | 0.05 | 0.07 |
| 8/RA | 329 | 91 (79–96) | 93 (74–96) | 88 (74–97) | 84 (66–94) | 75 (54–94) | 80 (64–89) | NS | 0.11 |
| 8/R0 | 338 | 9 (4–21) | 7 (4–26) | 12 (3–26) | 16 (6–34) | 26 (6–46) | 20 (11–36) | NS | 0.11 |
| 4/RA/62L | 282 | 77 (62–85) | 66 (53–78) | 62 (43–72) | 64 (52–77) | 54 (38–68) | 51 (42–64) | NS | 0.97 |
| 8/RA/62L | 236 | 75 (58–88) | 71 (30–83) | 62 (35–79) | 53 (34–76) | 49 (20–72) | 48 (28–70) | NS | 0.49 |
| γδ | 225 | 3 (2–5) | 5 (2–6) | 5 (3–8) | 7 (4–15) | 8 (5–18) | 9 (6–16) | NS | 0.47 |
| αβ | 224 | 94 (86–97) | 91 (84–96) | 90 (82–95) | 89 (81–94) | 88 (77–93) | 88 (79–93) | NS | 0.21 |
a
Values are medians (10th and 90th percentiles) and are presented as percentages of the total lymphocyte concentration except for the ratio of CD4 T lymphocytes to CD8+ T lymphocytes.
b
NS, not significant.