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IgG antibody responses of immunized mice as measured by ELISA. (A) Anti-fHbp. (B) Anti-LOS. The antigen on the plate was recombinant fHbp ID1 or LOS prepared from recombinant strain H44/76 ΔLpxL1. *, P < 0.05 for 10× fHbp NOMVs compared to NOMVs with 1× or 3× fHbp or recombinant fHbp vaccine (by Tukey's multiple comparison test). The differences between the respective anti-LOS antibody titers were not significant (P > 0.05).
