Table 1.
Determination of infection in rhesus macaques by measurement of bacteremia after aerosol exposure to B. anthracis Ames spores
| Animal | Gender | Challenge wt (kg) | LD50 equivalentc |
Bacteremia on day: |
First ciprofloxacin administration (h) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 (12 h) | 1 |
2 (48 h) | 3 (72 h) | 4 (96 h) | 5 (120 h) | 6 | 7 | |||||||
| 24 h | 30 h | 36 h | ||||||||||||
| RM1 | Male | 4.0 | 230 | − | − | − | − | + | − | − | − | − | − | NAa |
| RM2 | Male | 4.2 | 266 | − | − | + | + | − | − | − | − | − | − | 48 |
| RM3 | Female | 5.4 | 265 | − | − | + | + | +/−b | − | − | − | − | − | 48 |
| RM4 | Male | 5.6 | 207 | − | − | − | − | + | + | − | − | − | − | 72 |
| RM5 | Female | 2.8 | 243 | − | − | − | + | + | − | − | − | − | − | 72 |
a
NA, not applicable.
b
+/−, low positive result with only one to five colonies in the primary streak.
c
For Bacillus anthracis Ames, LD50 equivalent = inhaled dose (CFU/animal)/55,000 (where 55,000 is the reported LD50 of anthrax spores in rhesus monkeys [2]).