Table 5.
| Result(s) for acute-phase sample |
Result(s) for convalescent-phase sample |
Interpretation | ||||||
|---|---|---|---|---|---|---|---|---|
| IgM WNV positivity | IgM DENV positivity | NS1 positivity | RT-PCR DENV/WNV | IgM WNV positivity | IgM DENV positivity | NS1 positivity | PRNT90 with IgG depletion | |
| − | − | − | − | − | − | − | ND | Negative |
| +/− | +/− | − | + for WNV | +/− | +/− | − | ND | Confirmed WNV infection |
| +/− | +/− | +/− | + for DENV | +/− | +/− | +/− | ND | Confirmed DENV infection |
| + | + | + | − | + | + | +/− | + for DENV | Confirmed DENV infection |
| + | +2× >WNV | − | − | + | +2× >WNV | − | + for DENV | Presumed DENV infection |
| +2× >DENV | + | − | − | +2× >DENV | + | − | + for WNV | Presumed WNV infection |
a
With this table, a decision for the interpretation of the laboratory tests can be made for patients suspected of having WNV or DENV infection during cocirculation of both flaviviruses. Acute phase, 0 to 5 days after the onset of symptoms; convalescent phase, 6 to 14 days after the onset of symptoms; ND, not done; WNV, West Nile virus; DENV, dengue viruses; +/−, positive or negative; +2× >WNV, the sample's reactivity to the DENV antigen was >2-fold different from its reactivity to the WNV antigen; +2× >DENV, the sample's reactivity to the WNV antigen was >2-fold different from its reactivity to the DENV antigen.