Table 3.

Antibody titers in HLA class II alleles and haplotypes

Allele/haplotype	Antibody titera
	Anti-GAD				Anti-IA2
	Positive	Negative	Z	P	Positive	Negative	Z	P
DRB1*030101	73.10 ± 59.51	28.16 ± 17.08	3.87	<0.001	30.90 ± 24.52	21.89 ± 20.49	0.58	0.521
DRB1*040101	64.83 ± 52.68	52.93 ± 40.52	1.26	0.209	63.44 ± 56.44	25.20 ± 25.34	1.73	0.007
DRB1*070101	37.34 ± 21.42	60.08 ± 31.45	−3.30	0.001	20.94 ± 11.27	42.08 ± 31.45	−1.45	0.146
DRB1*110101	11.24 ± 4.35	58.62 ± 43.92	−3.51	<0.001	27.42 ± 12.80	58.48 ± 28.71	−2.57	0.010
DQB1*030101	17.22 ± 14.03	56.79 ± 39.74	−3.01	0.001	13.12 ± 12.87	29.77 ± 27.29	−1.73	0.083
DRB1*060101	26.68 ± 24.27	53.22 ± 49.19	−1.32	0.031	16.57 ± 15.21	29.41 ± 27.52	−0.07	0.365
DRB1*030101/DQB1*0201	114.72 ± 42.99	24.09 ± 25.39	2.77	<0.001	43.61 ± 44.71	29.14 ± 31.79	1.01	0.257
DRB1*040101/DQB1*0302	111.29 ± 49.97	52.12 ± 38.92	0.786	0.007	69.22 ± 53.07	25.17 ± 25.01	2.52	0.001
DRB1*070101/DQB1*0201	19.34 ± 15.36	60.24 ± 56.90	−3.24	0.001	25.17 ± 13.81	40.98 ± 30.42	−0.92	0.359
DRB1*110101/DQB1*030101	17.32 ± 15.56	98.30 ± 50.10	−3.25	0.001	15.89 ± 10.52	31.83 ± 23.81	−2.21	0.025

^aPositive, patients carrying the specific allele/haplotype; negative, other patients; Z, Z score. The values are mean ± SD antibody titers (AU/ml); differences in antibody titers between the patient groups were determined using a two-tailed Student t test.