Fig. 7.

Dynamic effects of asRNAs on the regulation of gene expression. (A) The speed of a regulatory response to environmental stress depends on the level at which control is exerted. The plot illustrates an example where the regulators have to be newly synthesized upon stress. (Adapted from reference 79 with permission of Macmillan Publishers Ltd. Copyright 2007.) In the time window soon after the onset of the downregulation, posttranscriptional regulation by RNAs is the fastest (gray region). (B) Schematic visualization of an asRNA-regulated, uncoordinated expression of genes within an operon, thereby tuning the amounts of gene products made from the different genes. Thus far, this mechanism has been described only qualitatively (66, 89, 97).