Table 5.
Comparison of patients with invasive infections due to hVISA and non-hVISA MRSA strains
| Variable | hVISA (n = 20) | Non-hVISA (n = 118) | Odds ratio (95% confidence interval) | P value |
|---|---|---|---|---|
| Age (median in yr) | 59 | 62 | 0.8 | |
| Black race [n (%)] | 9 (45) | 46 (39) | 1.2 (0.4–3.3) | 0.6 |
| Male [n (%)] | 11 (55) | 74 (62) | 1.3 (0.5–3.6) | 0.5 |
| HACO infection [n (%)] | 14 (70) | 71 (61) | 1.5 (0.5–4.3) | 0.4 |
| PFGE USA100 [n (%)] | 15 (75) | 84 (71) | 1.2 (0.4–3.6) | 0.7 |
| Hospitalized in prior yr [n (%)] | 17 (85) | 73 (62) | 3.5 (1.01–12.6) | 0.04 |
| Resident in a long-term care facility in prior yr [n (%)] | 9 (45) | 33 (28) | 2.1 (0.8–5.5) | 0.2 |
| ICU admission after initial culture [n (%)] | 3 (15) | 23 (19) | 0.7 (0.2–2.7) | 0.6 |
| Duration of therapy (median [days])a | 8 | 11 | 0.4 | |
| Duration of vancomycin (median [days])a | 6 | 8 | 0.4 | |
| Discharged on antibiotic [n (%)] | 11 (55) | 56 (47) | 1.4 (0.5–4.0) | 0.6 |
| MRSA-related complications [n (%)] | 6 (30) | 42 (36) | 0.7 (0.3–2.2) | 0.6 |
| Surgery in yr prior to infection [n (%)] | 7 (35) | 58 (49) | 0.6 (0.2–1.5) | 0.2 |
| Previous MRSA infection/colonization [n (%)] | 10 (50) | 36 (31) | 2.3 (0.9–5.9) | 0.08 |
| Initial MRSA culture isolated from bone or joint [n (%)] | 3 (15) | 6 (5) | 3.3 (0.8–14.4) | 0.09 |
| In-hospital mortality [n (%)] | 3 (15) | 20 (17) | 0.8 (0.2–3.2) | 0.8 |
| No. of patients with persistent MRSA bacteremia for ≥4 days/total no. of patients (n = 32)b | 4/4 (100) | 14/28 (50) | 0.06c | |
| MRSA recurrent disease [n (%)] | 3 (12) | 13 (16) | 0.7 (0.2–2.8) | 0.6 |
| Length of hospital stay (mean [days]) | 12 | 14 | 0.3 |
a
Includes only patients with treatment information available.
b
A total of 32 patients had persistent bacteremia, as defined by one or more positive MRSA blood cultures >24 h after the index culture.
c
Undefined odds ratio, as 100% of hVISA cases had ≥4 days of persistent bacteremia.