Table 1.
Patient | Sex | Risk factor(s) | Adherence to antituberculosis therapy | Episode no. | No. of days between episodes | Type of isolate | MIRU typeb |
---|---|---|---|---|---|---|---|
1 | Female | No | No | 1 | Sputum | 252353232232425 | |
2 | 568 | Sputum | 252353232232425 | ||||
3 | 469 | Sputum | 252353232232425 | ||||
4 | 356 | Sputum | 252353232232425 | ||||
2 | Male | IVDUc | No | 1 | Sputum | 245423342123217 | |
2 | 762 | Sputum | 245423342123217 | ||||
3 | Male | No | Not available | 1 | Sputum | 233543242212427 | |
2 | 870 | Sputum | 233543242212427 | ||||
4 | Male | HIV infection, IVDU, prison | No | 1 | Sputum | 253533233423533 | |
2 | 225 | Urine | 253533233423533 | ||||
5 | Male | No | No | 1 | Sputum | 253533333433426 | |
2 | 182 | Sputum | 253533333433426 | ||||
3 | 253 | Sputum | 253533333433426 | ||||
4 | 310 | Sputum | 253533333433426 | ||||
6 | Male | Alcoholism | Not available | 1 | Sputum | 25442342221243.11 | |
2 | 993 | Sputum | 25442342221243.11 | ||||
7 | Male | Alcoholism | No | 1 | Sputum | 25453342221243.11 | |
2 | 1,120 | Sputum | 25453342221243.11 | ||||
8 | Male | HIV infection, IVDU | No | 1 | Sputum | 2′52453242232225 | |
2 | 753 | Sputum | 2′52453242232225 | ||||
3 | 567 | Sputum | 2′52453242232225 | ||||
9 | Female | HIV infection, IVDU | Not available | 1 | Sputum | 2515_3333433726 | |
2 | 714 | Sputum | Not available | ||||
10 | Male | HIV infection, IVDU | Not available | 1 | Urine | 252433422212437 | |
2 | 1,367 | Sputum | 2534_3342133137 | ||||
11 | Male | HIV infection, alcoholism | Not available | 1 | Sputum | 252533233432425 | |
2 | 602 | Sputum | 252333233432425 | ||||
12 | Male | HIV infection, alcoholism, prison | Not available | 1 | Sputum | 253333243232325 | |
2 | 1,492 | Sputum | 252333243232325 | ||||
Sputum | 252333243232325 | ||||||
13 | Male | No | Not available | 1 | Sputum | 252343232232125 | |
2 | 863 | Sputum | 252343232232125 | ||||
14 | Male | HIV infection, alcoholism | Yes | 1 | Sputum | 255323143232525 | |
2 | 1,888 | Sputum | 255433340211434 | ||||
3 | 327 | Urine | 255433340211434 | ||||
15 | Male | HIV infection | Not available | 1 | Sputum | 253323422212236 | |
2 | 288 | Sputum | 253323422212236 | ||||
16 | Male | Silicosis, lupus | Yes | 1 | Sputum | 252433243443347 | |
Sputum | 252433243443347 | ||||||
2 | 1,963 | Sputum | 252433243443347 | ||||
17 | Male | HIV infection, IVDU, hepatitis B, | Yes | 1 | Sputum | 253333242232425 | |
hepatitis C | Sputum | 253333242232425 | |||||
2 | 409 | Blood | 253333242232425 | ||||
18 | Male | HIV infection, IVDU, hepatitis B, | No | 1 | Sputum | 254223422213236 | |
hepatitis C | 2 | 238 | CSFd | 254223422213236 | |||
19 | Male | No | Not available | 1 | Sputum | 333333444232416 | |
Sputum | 333333444232416 | ||||||
2 | 489 | Sputum | 243433422212434 | ||||
20 | Male | Alcoholism, smoking | Yes | 1 | Sputum | 251433542122438 | |
2 | 202 | Sputum | 251433542122438 | ||||
21 | Male | No | Not available | 1 | Sputum | 263432233431244 | |
Sputum | 263432233431244 | ||||||
2 | 263 | Sputum | 252343242232325 | ||||
22 | Female | Alcoholism, smoking | No | 1 | Sputum | 253423422212334 | |
2 | 387 | Sputum | 253423422212334 | ||||
23 | Male | HIV infection, alcoholism | Not available | 1 | Sputum | 253423422212437 | |
Sputum | 253423422212437 | ||||||
2 | 610 | Sputum | 253423422212437 | ||||
24 | Male | HIV infection, IVDU, hepatitis B, | Yes | 1 | Sputum | 243433442212424 | |
hepatitis C | Sputum | 243433442212424 | |||||
2 | 321 | Sputum | 243433442212424 | ||||
Sputum | 243433442212424 | ||||||
25 | Male | HIV infection, alcoholism, | No | 1 | Sputum | 253633233433635 | |
homelessness | 2 | 981 | Sputum | 253532233333235 | |||
26 | Male | No | Not available | 1 | Sputum | 255433442212334 | |
Sputum | 255433442212334 | ||||||
2 | 252 | Sputum | 255433442212334 | ||||
Sputum | 255433442212334 | ||||||
3 | 1,203 | Sputum | 255433442212334 | ||||
27 | Female | No | Not available | 1 | Sputum | 251343142232225 | |
2 | 1,036 | Sputum | 354323343222518 | ||||
28 | Male | No | Not available | 1 | Sputum | 251323142122234 | |
Sputum | 251323142122234 | ||||||
2 | 221 | Sputum | 251323142122234 | ||||
29 | Male | No | Not available | 1 | Sputum | 254233242232425 | |
2 | 258 | Sputum | 254233242232425 | ||||
30 | Male | HIV infection, IVDU, hepatitis C | Yes | 1 | Sputum | 253533242232425 | |
Sputum | 253533242232425 | ||||||
2 | 285 | Sputum | 253533242232425 | ||||
31 | Male | HIV infection, IVDU, hepatitis B, | Unknown | 1 | Sputum | 251423442122337 | |
hepatitis C | 2 | 312 | Sputum | 251423442122337 | |||
32 | Female | HIV infection, IVDU, hepatitis C | No | 1 | Sputum | 252343242232325 | |
2 | 186 | Sputum | 252343242232325 | ||||
33 | Male | HIV infection, IVDU, hepatitis B, | No | 1 | Sputum | 253533233433426 | |
hepatitis C, prison | Sputum | 253533233433426 | |||||
2 | 277 | Sputum | 253533233433426 | ||||
34 | Male | HIV infection, IVDU, alcoholism | No | 1 | Sputum | 251423442122337 | |
Sputum | 251423442122337 | ||||||
2 | 217 | Blood | 244333043_3_525 | ||||
35 | Male | HIV infection, IVDU, hepatitis C | Yes | 1 | Sputum | 234333242232325 | |
Sputum | 234333242232325 | ||||||
2 | 222 | Sputum | 234333242232325 | ||||
36 | Male | Alcoholism, smoking, hepatitis C | No | 1 | Sputum | 252433342123237 | |
2 | 880 | Sputum | 252433342123237 | ||||
37 | Male | HIV infection, multidrug user | No | 1 | Sputum | 261423342132235 | |
2 | 425 | Sputum | 261423142132235 | ||||
Sputum | 261423142132235 | ||||||
38 | Male | No | Yes | 1 | Sputum | 351433233423436 | |
2 | 1,400 | Sputum | 351433233423436 | ||||
39 | Male | HIV infection, hepatitis C, | Not available | 1 | Sputum | 251323442122438 | |
IVDU, smoking | Sputum | 251323442122438 | |||||
2 | 1,472 | Sputum | 251623442122337 | ||||
Sputum | 251623442122337 | ||||||
Sputum | 251623442122337 | ||||||
Sputum | 251623442122337 | ||||||
Sputum | 251623442122337 | ||||||
Sputum | 251623442122337 | ||||||
Sputum | 251623442122337 | ||||||
Sputum | 251623442122337 | ||||||
40 | Male | HIV infection, hepatitis C, | No | 1 | Sputum | 263335444432647 | |
IVDU, smoking | Sputum | 263335444432647 | |||||
2 | 304 | Sputum | 263335444432647 | ||||
Sputum | 263335444432647 | ||||||
Sputum | 263335444432647 | ||||||
Sputum | 263335444432647 | ||||||
3 | 382 | Sputum | 263335444432647 | ||||
Sputum | 263335444432647 | ||||||
Urine | 263335444432647 | ||||||
Urine | 263335444432647 | ||||||
Urine | 263335444432647 | ||||||
Pleural fluid | 263335444432647 | ||||||
Pleural fluid | 263335444432647 |
Those cases in which clonal complexity was detected are highlighted in gray.
Loci at which the isolates show differences in their MIRU types are in boldface. The lack of an allelic value at an MIRU locus indicates that no amplified product was obtained. In patients 6 and 7, the allele in the last locus in the MIRU type corresponded to a value of 11.
IVDU, intravenous drug user.
CSF, cerebrospinal fluid.