Table 1.
Overall organism recovery and average TTD by medium type and antibiotic concentrations
| Medium | Drug (T, M, P concn)a | Statisticb | Total no. of bottles | No. of bottles with indicated Bactec result (% of bottles) |
No. of bottles with indicated TREK result (% of bottles) |
P value for: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Trough | Midlevel | Peak | Control | Trough | Midlevel | Peak | Control | Trough | Midlevel | Peak | ||||
| Aerobic | Recovered | 84 | 84 (100) | 65 (77.4) | 50 (59.5) | 33 (39.3) | 84 (100) | 35 (41.7) | 10 (11.9) | 2 (2.4) | 1.000 | <0.001 | <0.001 | <0.001 | |
| Avg TTD | 12.6 | 18 | 20.9 | 23 | 12.7 | 20.1 | 38.2 | 21.3 | |||||||
| Combined | 148/252 (58.7) | 47/252 (18.6) | |||||||||||||
| Anaerobic | Recovered | 30 | 30 (100) | 19 (63.3) | 16 (53.3) | 15 (50) | 29 (96.7) | 6 (20) | 5 (16.7) | 0 (0) | 1.000 | <0.001 | 0.006 | <0.001 | |
| Avg TTD | 11.8 | 18 | 25 | 30 | 15.8 | 14.8 | 47.4 | NAc | |||||||
| Combined | 50/90 (55.5) | 11/90 (12.2) | |||||||||||||
| Overall | 114 | 114 (100) | 198/342 (57.8) | 113 (99.1) | 58/342 (16.9) | ||||||||||
| Aerobic | Ampicillin (3, 12, 47) | Recovered | 9 | 9 (100) | 9 (100) | 6 (66.7) | 3 (33.3) | 9 (100) | 4 (44.4) | 0 (0) | 1 (11.1) | 1.000 | 0.029 | 0.009 | 0.577 |
| Avg TTD | 11.3 | 16.2 | 20.9 | 21.8 | 11.8 | 25.1 | NA | 30.7 | |||||||
| Anaerobic | Recovered | 6 | 6 (100) | 4 (66.7) | 1 (16.7) | 0 (0) | 5 (83.3) | 0 (0) | 0 (0) | 0 (0) | 1.000 | 0.061 | 1.000 | 1.000 | |
| Avg TTD | 11.3 | 21.1 | 63.8 | NA | 16.4 | NA | NA | NA | |||||||
| Aerobic | Cefepime (4, 19, 164) | Recovered | 12 | 12 (100) | 6 (50) | 3 (25) | 0 (0) | 12 (100) | 6 (50) | 0 (0) | 0 (0) | 1.000 | 1.000 | 0.217 | 1.000 |
| Avg TTD | 13.6 | 20.8 | 32 | NA | 12.8 | 33.4 | NA | NA | |||||||
| Aerobic | Ceftriaxone (15, 46, 250) | Recovered | 9 | 9 (100) | 0 (0) | 0 (0) | 0 (0) | 9 (100) | 0 (0) | 0 (0) | 0 (0) | ||||
| Avg TTD | 12.1 | NA | NA | NA | 13.3 | NA | NA | NA | |||||||
| Anaerobic | Recovered | 9 | 9 (100) | 0 (0) | 0 (0) | 0 (0) | 9 (100) | 0 (0) | 0 (0) | 0 (0) | |||||
| Avg TTD | 12.5 | NA | NA | NA | 17.6 | NA | NA | NA | |||||||
| Aerobic | Levofloxacin (1.3, 4.5, 12) | Recovered | 18 | 18 (100) | 14 (77.8) | 10 (55.6) | 7 (38.9) | 10 (100) | 13 (72.2) | 8 (44.4) | 0 (0) | 1.000 | 1.000 | 0.740 | 0.008 |
| Avg TTD | 13.5 | 14.7 | 16 | 12.2 | 13.6 | 18.6 | 37.2 | NA | |||||||
| Anaerobic | Recovered | 6 | 6 (100) | 6 (100) | 6 (100) | 6 (100) | 6 (100) | 6 (100) | 5 (83.3) | 0 (0) | 1.000 | 1.000 | 1.000 | 0.002 | |
| Avg TTD | 11.6 | 11 | 11.3 | 11.6 | 13.1 | 14.8 | 47.4 | NA | |||||||
| Aerobic | Piperacillin-tazobactam (1.4-0.2, 16-2, 298-37) | Recovered | 12 | 12 (100) | 12 (100) | 9 (75) | 4 (33.3) | 12 (100) | 12 (100) | 2 (16.7) | 0 (0) | 1.000 | 1.000 | 0.012 | 0.093 |
| Avg TTD | 14.3 | 14.2 | 16.9 | 16.9 | 13.2 | 13.5 | 42.4 | ||||||||
| Aerobic | Vancomycin (10, 25, 50) | Recovered | 24 | 24 (100) | 24 (100) | 22 (91.7) | 19 (79.2) | 24 (100) | 0 (0) | 0 (0) | 1 (4.2) | 1.000 | <0.001 | <0.001 | <0.001 |
| Avg TTD | 11.2 | 21.7 | 23.3 | 28.4 | 11.9 | NA | NA | 11.9 | |||||||
| Anaerobic | Recovered | 9 | 9 (100) | 9 (100) | 9 (100) | 9 (100) | 9 (100) | 0 (0) | 0 (0) | 0 (0) | |||||
| Avg TTD | 11.7 | 21.3 | 29.8 | 42.2 | 15.4 | NA | NA | NA | |||||||
a
Antibiotic concentrations (μg/ml) at trough, midlevel, and peak.
b
“Recovered” means the number of bottles from which organisms were recovered. TTDs are in hours (values are rounded to the nearest decimal). “Combined” means the summed number of T, M, and P bottles in which organisms were recovered/total number of bottles tested.
c
NA, not applicable (no organism growth in any bottles).