Table 1.
Numbers of Large-Scale Duplications and Deletions Inferred in Human Gene Clusters Following Divergence from Various Mammalian Clades
| Cluster | Location | GA | OWM | NWM | LG | DOG |
|---|---|---|---|---|---|---|
| CYP4 | chr1:47048227–47411959 | 1, 0 | 4, 1 | 4, 1 | 5, 1 | 10, 1 |
| LCE | chr1:150776235–151067237 | 0, 0 | 0, 0 | 5, 1 | 6, 1 | 9, 2 |
| CR, DAP3 | chr1:153784948–154023311 | 0, 0 | 3, 2 | 12, 2 | 19, 5 | 21, 7 |
| FC | chr1:159742726–159915333 | 1, 2 | 1, 2 | 3, 2 | 4, 2 | 4, 2 |
| CR1 | chr1:205701588–205958677 | 1, 0 | 7, 0 | 8, 3 | 8, 3 | 10, 3 |
| CCDC, CFC1 | chr2:130461934–131153411 | 3, 0 | 5, 0 | 7, 5 | 7, 5 | 10, 5 |
| CXCL, IL8 | chr4:74781081–75209572 | 0, 0 | 0, 0 | 0, 0 | 2, 1 | 17, 8 |
| PCDH | chr5:140145736–140851366 | 0, 0 | 0, 0 | 0, 0 | 1, 0 | 36, 0 |
| HLA | chr6:29786467–30568761 | 0, 0 | 2, 0 | 27, 3 | 38, 5 | 50, 6 |
| HLA-D | chr6:33082752–33265289 | 0, 0 | 0, 0 | 0, 0 | 4, 3 | 6, 8 |
| OR2 | chr7:143005241–143760083 | 6, 1 | 8, 1 | 8, 1 | 10, 1 | 16, 1 |
| AKR1C | chr10:4907977–5322660 | 0, 0 | 3, 2 | 4, 3 | 9, 4 | 28, 4 |
| GAD2 | chr10:26458036–27007198 | 0, 0 | 4, 0 | 6, 1 | 15, 2 | 17, 2 |
| PNLIP | chr10:118205218–118387999 | 0, 0 | 0, 0 | 1, 0 | 2, 1 | 5, 2 |
| OR5, HB, TRIM | chr11:4124149–6177952 | 6, 0 | 7, 0 | 9, 0 | 9, 0 | 24, 2 |
| LST3, SLCO1B | chr12:20846959–21313050 | 0, 0 | 0, 0 | 0, 0 | 9, 2 | 21, 3 |
| C14orf | chr14:23177922–23591420 | 1, 0 | 4, 0 | 5, 2 | 6, 2 | 8, 3 |
| CYP1A1 | chr15:71687352–74071019 | 2, 0 | 12, 2 | 21, 3 | 23, 4 | 25, 4 |
| ACSM | chr16:20234773–20711192 | 2, 0 | 4, 2 | 4, 2 | 4, 2 | 5, 2 |
| LGALS9, NOS2A | chr17:22979762–23370074 | 0, 0 | 2, 0 | 2, 2 | 2, 2 | 3, 2 |
| OR, ZNF | chr19:8569586–9765797 | 4, 0 | 6, 0 | 14, 0 | 23, 0 | 33, 0 |
| NPHS1, ZNF | chr19:40976726–43450858 | 0, 0 | 6, 1 | 12, 1 | 16, 2 | 23, 4 |
| CYP2A | chr19:46016475–46404199 | 0, 0 | 5, 0 | 11, 3 | 14, 3 | 16, 3 |
| DGCR6L, ZNF74 | chr22:18594272–19312230 | 3, 0 | 4, 0 | 5, 1 | 5, 1 | 5, 1 |
| SLC5A, YWHAH | chr22:30379202–31096691 | 0, 0 | 3, 1 | 4, 1 | 6, 1 | 7, 1 |
GA, great apes (matches of at least 98% similarity); OWM, old world monkeys (93%); NWM, new world monkeys (89%); LG, lemurs and galagos (85%); DOG, dogs (80%). Cluster locations are indicated as coordinates in the March 2006 human genome sequence assembly.