TABLE 4.
Lipid-associated SNPs with P < 0.0001 in the NOMAS Subcohort or Dominican Subset
| Chr | SNP | BP | Minor/Major Allele (MAF) | Lead Trait | Beta (SE)b | P c | Other Lipid Traitsa,d | Gene Nearby | |
| All NOMAS Subcohort | NOMAS Dominican Subset | ||||||||
| 7 | rs4947638 | 51794849 | T/C (0.26) | T/C (0.23) | LDL-C/HDL-C | −0.10 (0.02) | 3.27×10−5 | HDL-C; LDL-C/HDL-C, HDL-C | LOC100131871 |
| rs7785376 | 51923383 | G/A (0.17) | G/A (0.14) | HDL-C | 0.08 (0.02) | 2.25×10−5−5 | LDL-C/HDL-C, TG | LOC100131871 | |
| rs13235686 | 54095049 | G/A (0.12) | G/A (0.13) | LDL-C/HDL-C | 0.13 (0.03) | 3.34×10−5 | LDL-C; LDL-C/HDL-C LDL-C | FLJ45974/ SLC25A5P3 | |
| rs17560050 | 54095274 | C/A (0.14) | C/A (0.14) | LDL-C/HDL-C | 0.12 (0.03) | 2.60×10−5−5 | LDL-C; LDL-C/HDL-C, LDL-C | FLJ45974/ SLC25A5P3 | |
| rs17560056 | 54095333 | G/C (0.14) | G/C (0.14) | LDL-C/HDL-C | 0.12 (0.03) | 2.60×10−5−5 | LDL-C; LDL-C/HDL-C, LDL-C | FLJ45974/ SLC25A5P3 | |
| rs10499728 | 54098093 | A/G (0.14) | A/G (0.14) | LDL-C/HDL-C | 0.12 (0.03) | 8.45×10−5 | LDL-C; LDL-C/HDL-C | FLJ45974/ SLC25A5P3 | |
| rs13233885 | 54099495 | C/T (0.14) | C/T (0.14) | LDL-C/HDL-C | 0.12 (0.03) | 2.60×10−5−5 | LDL-C; LDL-C/HDL-C, LDL-C | FLJ45974/ SLC25A5P3 | |
| rs7806473 | 54100065 | C/T (0.11) | C/T (0.12) | LDL-C/HDL-C | 0.14 (0.03) | 9.24×10−6−5 | LDL-C, HDL-C; LDL-C, LDL-C/HDL-C | FLJ45974/ SLC25A5P3 | |
| rs953160 | 54104682 | G/A (0.13) | G/A (0.14) | LDL-C/HDL-C | 0.13 (0.03) | 2.52×10−5−5 | LDL-C; LDL-C/HDL-C, LDL-C | FLJ45974/ SLC25A5P3 | |
| rs17560210 | 54110101 | C/T (0.14) | C/T (0.15) | LDL-C/HDL-C | 0.12 (0.03) | 3.42×10−5 | LDL-C; LDL-C/HDL-C | FLJ45974/ SLC25A5P3 | |
| rs13238899 | 56108112 | C/A (0.09) | C/A (0.10) | LDL-C | −0.10 (0.03) | 7.02×10−5 | LDL-C/HDL-C, TC; LDL-C | SUMF2 | |
| 15 | rs17758593 | 68100336 | T/C (0.11) | T/C (0.11) | LDL-C | −0.12 (0.03) | 8.13×10−5 | TC, LDL-C/HDL-C | TLE3 |
| rs3858961 | 78394769 | A/G (0.15) | A/G (0.17) | HDL-C | −0.08 (0.02) | 6.29×10−5 | TC, LDL-C/HDL-C | FAH | |
| rs4778823 | 78649800 | G/T (0.14) | G/T (0.15) | LDL-C | −0.09 (0.02) | 6.35×10−5 | TC, LDL-C/HDL-C | ARNT2 | |
| rs1482937 | 79598554 | G/C (0.33) | G/C (0.30) | LDL-C | −0.06 (0.02) | 4.99×10−5 | TMC3 | ||
| rs7179520 | 89972904 | G/C (0.18) | G/C (0.16) | LDL-C/HDL-C | −0.11 (0.03) | 1.65×10−5−5 | HDL-C | LOC441732 | |
| rs4932506 | 89976260 | A/G (0.14) | A/G (0.11) | LDL-C/HDL-C | −0.14 (0.03) | 5.05×10−6−5 | HDL-C | LOC441732 | |
| 16 | rs4357934 | 82148718 | G/C (0.32) | G/C (0.32) | TC | 0.05 (0.01) | 9.13×10−5 | LDL-C, LDL-C/HDL-C | CDH13 |
| rs11645264 | 82159785 | T/C (0.34) | T/C (0.35) | TC | −0.05 (0.01) | 9.25×10−5 | LDL-C, LDL-C/HDL-C; TC, LDL-C | CDH13 | |
| 19 | rs1216119 | 22501685 | T/G (0.29) | T/G (0.27) | LDL-C/HDL-C | −0.12 (0.03) | 9.03×10−5 | TC, LDL-C, HDL-C, TG | LOC100128139 |
| rs7245570 | 36505242 | A/G (0.05) | A/G (0.06) | LDL-C | −0.13 (0.03) | 5.23×10−5 | TC, LDL-C/HDL-C; LDL-C, TC, LDL-C/HDL-C | TSHZ3 | |
| rs10417470 | 36896151 | C/T (0.48) | T/C (0.47) | LDL-C/HDL-C | 0.08 (0.02) | 7.27×10−5 | HDL-C | TSHZ3 | |
| 20 | rs1547063 | 2427198 | G/A (0.35) | G/A (0.35) | TC | 0.06 (0.01) | 6.15×10−5 | LDL-C, LDL-C/HDL-C; | ZNF343 |
| rs6037842 | 4366157 | G/A (0.10) | G/A (0.12) | LDL-C/HDL-C | 0.19 (0.04) | 1.61×10−5−5 | LDL-C, HDL-C, TG; HDL-C, LDL-C/HDL-C | RPL7AL2 | |
Chr, chromosome; BP, base pair.
a
All lipid traits were log-transformed. Traits in italics apply only to the Dominican subset; otherwise, traits apply to the entire NOMAS subcohort.
b
Regression coefficient and its standard error (SE) were based on additive genetic effect model after adjustment for significant covariates.
c
P values are bolded if they had a Bonferroni-corrected P < 0.05 based on the effective number of tests within the linkage peak.
d
Traits were included if the associated P < 0.01 in the entire MONAS subcohort or if P < 0.02 in the NOMAS Dominican subset.