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(A) Idiogram illustrating normal chromosome 16 and chromosome 16 with tandem duplication of the 16q12.1-q21 region (demarcated by lines). (B) High resolution karyotype, GTG banding showing the suspected interstitial dup16q13-q22. (C) Fluorescence in situ hybridization analysis using whole chromosome 16 painting probe on a metaphase of the proband demonstrated that both chromosomes 16 were completely colored.
