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. 2011 Apr 25;117(24):6571–6581. doi: 10.1182/blood-2011-01-329417

Figure 5.

Figure 5

PPARγ is required to decrease expression of IL-9, IL-10, IL-13, and VEGFα. wtNKG2D T cells were stimulated with anti-CD3/CD28–, anti-CD3–, anti-NKG2D–, or anti-CD3 and anti-NKG2D–coated beads in the presence of PPARγ inhibitor GW9662 (1.0μM) or DMSO vehicle control (0μM). After 8 hours, gene expression was determined by RT-PCR. Data are shown as the fold change in gene expression compared with T cells cultured in media at each concentration of inhibitor. Data shown were obtained from 1 donor and are representative of data from 3 donors. Stimulation of T cells through NKG2D significantly changed gene expression compared with CD3 stimulation (**P < .05), and the presence of the inhibitor significantly changed gene expression compared with NKG2D stimulation in the presence of vehicle control (***P < .05).