Table 3.
Results of Z and S allele carriage determining α1AT deficiency and association with WG according to ANCA pattern*
| Genotype | Cases, no. (%) | Controls, no. (%) | OR (95% CI) | P |
|---|---|---|---|---|
| Anti–PR3 ANCA positive | ||||
| MM | 277 (81.7) | 371 (88.1) | 1 (reference) | – |
| MS and MZ | 54 (15.9) | 50 (11.9) | 1.45 (0.94–2.24) | 0.10 |
| SS, ZZ, and SZ | 8 (2.4) | 0 (0) | 14.72 (2.26–∞) | 0.002 |
| Anti–MPO ANCA positive | ||||
| MM | 38 (86.4) | 371 (88.1) | 1 (reference) | – |
| MS and MZ | 6 (16.6) | 50 (11.9) | 1.17 (0.39–2.99) | 0.88 |
| SS, ZZ and SZ | 0 (0) | 0 (0) | NA | NA |
| Anti–PR3/MPO ANCA negative | ||||
| MM | 27 (69.2) | 371 (88.1) | 1 (reference) | – |
| MS and MZ | 10 (25.6) | 50 (11.9) | 2.74 (1.12–6.28) | 0.03 |
| SS, ZZ, and SZ | 2 (5.1) | 0 (0) | 31.81 (2.45–∞) | 0.01 |
*
OR = odds ratio; 95% CI = 95% confidence interval; NA = not applicable (see Table 1 for other definitions).