FIGURE 4.

UA treatment ameliorated EAE disease in mice. For EAE induction, mice were given either DMSO or UA by i.p. injection every other day after the first MOG immunization and monitored daily for clinical symptom development after the second MOG immunization. Results are the combination of two independent EAE experiments, and the disease onset date of DMSO-treated mice was set to day 1 for statistical analysis. A, the percentage of mice that developed EAE disease (n = 10 for DMSO group and n = 8 for UA group). B, the clinical scores of diseased mice (n = 7 for the DMSO group and n = 6 for the UA group). C, the total number of CD4⁺, IL-17⁺, and IFN-γ⁺ cells in the central nervous system of EAE mice. D, the effect of UA on MOG-specific IL-17 production in the spleens of EAE mice.