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. 2011 May 5;286(26):22785–22794. doi: 10.1074/jbc.M111.233577

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Furin is the major pro-BMP10 cleaving enzyme in hepatocytes. Primary hepatocytes isolated from WT mice and those lacking PC5/6 (PC5/6-KO) or furin (Fur-KO) in hepatocytes (22) were transiently transfected with plasmids expressing no protein (vector) or (ProtC)-BMP10. Processing of pro-BMP10 into its prosegment was analyzed in 48-h conditioned medium by immunoprecipitation (IP) with a rabbit ProtC-Ab followed by Western blotting (WB) using the same antibody. The percentages (%) of cleavages in this particular experiment are indicated, along with the average % cleavage and S.D. values of two independent experiments.