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Ouabain activated c-Src and ERK1/2 and enhanced association between c-Src and the α1 subunit in RPTs of the R rats, but not the S rats. RPTs were isolated from the R and S rats fed with low salt (0.3% NaCl) diet. Ouabain treatments (Oua, 1 and 10 μmol/liter for 5 min) stimulated c-Src phosphorylation and its association with the α1 subunit (a) and activated ERK1/2 (b). Values are expressed relative to a control value of 100. n = 4. **, p < 0.01.
